Book The Best Hotels in Upstate South Carolina, SC for 2026 from CA $94 - Fully Refundable Options

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Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

CA $117 total

includes taxes & fees

Dec 6 - Dec 7

A modern kitchen with hanging light fixtures and bar seating.

2. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Angie

CA $169 total

includes taxes & fees

Nov 29 - Nov 30

A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

3. Hilton Garden Inn Greenville

Greenville

Valerie

CA $156 total

includes taxes & fees

Nov 27 - Nov 28

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

4. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

CA $156 total

includes taxes & fees

Nov 23 - Nov 24

A modern hotel room with a large bed, a desk, and a kitchenette.

5. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Maclin

CA $111 total

includes taxes & fees

Nov 24 - Nov 25

A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

6. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Sam

CA $150 total

includes taxes & fees

Dec 7 - Dec 8

A spacious lobby with a modern design, featuring a reception desk, seating area with sofas and armchairs, and a large chandelier.

7. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

George

CA $155 total

includes taxes & fees

Dec 10 - Dec 11

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

8. Drury Inn & Suites Greenville

Greenville

ruth

CA $179 total

includes taxes & fees

Nov 16 - Nov 17

A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.

9. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Joseph

CA $163 total

includes taxes & fees

Nov 24 - Nov 25

A modern hotel lobby with a bar area, seating, and a reception desk.

10. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Rick

CA $165 total

includes taxes & fees

Dec 7 - Dec 8

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

11. Tru by Hilton Greenville Woodruff Road

Greenville

Amy

CA $175 total

includes taxes & fees

Nov 26 - Nov 27

A Holiday Inn Express & Suites with a covered entrance and a clear sky.

12. Holiday Inn Express & Suites Greenville-I-85 & Woodruff Rd by IHG

Greenville

Jammie

CA $178 total

includes taxes & fees

Dec 7 - Dec 8

A hotel room with two beds, a bedside table, a lamp, and a window with curtains.

13. Clarion Inn

Greenville

Johnny

CA $110 total

includes taxes & fees

Nov 29 - Nov 30

A Comfort Inn hotel with a stone facade, a clear sign indicating a 12'6" clearance, and a well-lit entrance.

14. Comfort Inn Greenville - Haywood Mall

Greenville

Paul

CA $142 total

includes taxes & fees

Dec 6 - Dec 7

A spacious lobby with modern furniture, a chandelier, and potted plants.

15. Hilton Greenville

Greenville

Monique

CA $166 total

includes taxes & fees

Dec 7 - Dec 8

A modern hotel room with a large bed, a bathtub, and a wall-mounted artwork.

16. Days Inn by Wyndham Greenville South/Mauldin

Mauldin

Mark

CA $114 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bed, two bedside lamps, a desk with a telephone, and a chair.

17. Candlewood Suites Greenville by IHG

Greenville

Lucy

CA $157 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a sofa, a coffee table, a TV, a desk, and a bed.

18. Best Western Plus Greenville South

Piedmont

David

CA $145 total

includes taxes & fees

Nov 11 - Nov 12

A modern lounge area with two armchairs, a small round table, and a fireplace.

19. Hampton Inn Easley

Easley

Kathi

CA $192 total

includes taxes & fees

Dec 10 - Dec 11

A circular outdoor seating area with a fire pit, surrounded by sofas and chairs, in front of a multi-story building.

20. Courtyard by Marriott Greenville Haywood Mall

Greenville

alejandro

CA $175 total

includes taxes & fees

Nov 30 - Dec 1

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Compare top hotels in Upstate South Carolina

Best Western Plus Greenville I-385 Inn & Suites 2.5 star property Greenville View	DoubleTree by Hilton Greenville Woodruff Road 3.0 star property Greenville View	Hilton Garden Inn Greenville 3.0 star property Greenville View	Embassy Suites Greenville Golf Resort & Conference Center 3.5 star property Greenville View	Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd 2.0 star property Greenville View
9.2 Wonderful 1,616 reviews	9.2 Wonderful 1,003 reviews	8.8 Excellent 1,001 reviews	9.0 Wonderful 1,471 reviews	8.4 Very good 1,004 reviews
The price is CA $106 CA $117 total includes taxes & fees Dec 6 - Dec 7	The price is CA $149 CA $169 total includes taxes & fees Nov 29 - Nov 30	The price is CA $138 CA $156 total includes taxes & fees Nov 27 - Nov 28	The price is CA $138 CA $156 total includes taxes & fees Nov 23 - Nov 24	The price is CA $101 CA $111 total includes taxes & fees Nov 24 - Nov 25
Yes, Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included No Pool No Spa No Pet-friendly No WiFi included Yes, Parking

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.

Hotel Hartness

Greenville

10/10 Excellent

What a gem!! Definitely the place to stay when in Greenville, or even to visit specifically as a vacation. It’s not in the city (about 15min drive) and that’s the beauty of this place: it’s away from touristy stuff, and in the middle of nature, but close enough to the city that you can always go and visit. The service was 6 star! All the staff were super friendly, and while a part of it is “southern hospitality “, there for sure is an added factor of the culture of the hotel. Great dining...