Photo by RVLuckyorWhat
Find hotels in Upstate South Carolina, SC from CA $90
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Family friendly
Check prices for these dates
Our top choices for Upstate South Carolina hotels
Hampton Inn Gaffney
Hampton Inn GaffneyGaffney
8.8 out of 10, Excellent, (734 reviews)
"Everything was great!"
Cristen
The price is CA $124
CA $135 total
includes taxes & fees
Jul 4 - Jul 5
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
9.4 out of 10, Exceptional, (240 reviews)
"Excellent in every way … staff, room, amenities and very comfortable bed!"
Sarah
The price is CA $171
CA $188 total
includes taxes & fees
Jul 2 - Jul 3
Carolina Inn Anderson Clemson Area
Carolina Inn Anderson Clemson AreaAnderson
8.4 out of 10, Very good, (9 reviews)
"The staff is great "
Luis Fernando
The price is CA $67
CA $81 total
includes taxes & fees
Jul 2 - Jul 3
Holiday Inn Express Gaffney by IHG
Holiday Inn Express Gaffney by IHGGaffney
8.8 out of 10, Excellent, (511 reviews)
"Room very clean staff was great breakfast was really good with lots of options "
melvin
The price is CA $135
CA $147 total
includes taxes & fees
Jun 28 - Jun 29
Tru by Hilton Spartanburg
Tru by Hilton SpartanburgSpartanburg
9.2 out of 10, Wonderful, (926 reviews)
"Wonderful rooms, helpful staff, and probably the best breakfast I have seen anywhere"
Hester L.
The price is CA $141
CA $157 total
includes taxes & fees
Jul 9 - Jul 10
The Point At Lake Hartwell
The Point At Lake HartwellTownville
The price is CA $163
CA $181 total
includes taxes & fees
Jul 7 - Jul 8
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.Greenville
8.6 out of 10, Excellent, (266 reviews)
"Hotel is near shopping and Restaurants"
Kristina
The price is CA $112
CA $124 total
includes taxes & fees
Jul 9 - Jul 10
Deluxe Inn
Deluxe InnMauldin
9.6 out of 10, Exceptional, (4 reviews)
"Jarod was very helpful and friendly. Amazing location. Within 1/2 mi several restaurants as well as 2 grocery stores. Very safe area as well as friendly folk. So close to Greenville concert hall. Definitely will stay again."
Diane
The price is CA $82
CA $90 total
includes taxes & fees
Jul 2 - Jul 3
Hilton Garden Inn Anderson
Hilton Garden Inn AndersonAnderson
9.0 out of 10, Wonderful, (742 reviews)
"Great place to stay"
Maureen
The price is CA $141
CA $156 total
includes taxes & fees
Jul 3 - Jul 4
Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
9.6 out of 10, Exceptional, (469 reviews)
"Parking is very convenient to the hotel. The room was clean and the beds were very comfortable. Breakfast was good and there was a large variety of choices. Excellent stay!"
Trina
The price is CA $197
CA $215 total
includes taxes & fees
Jul 2 - Jul 3
Hampton Inn & Suites Clinton - I-26
Hampton Inn & Suites Clinton - I-26Clinton
9.0 out of 10, Wonderful, (752 reviews)
"The breakfast was very good and the set up was excellent. "
Sarah
The price is CA $156
CA $175 total
includes taxes & fees
Jul 12 - Jul 13
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
9.2 out of 10, Wonderful, (1,517 reviews)
"Location was very convenient and the breakfast was nice."
Shabana
The price is CA $131
CA $144 total
includes taxes & fees
Jul 5 - Jul 6
Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,001 reviews)
"We loved it and we will visit again."
Kelly
The price is CA $155
CA $192 total
includes taxes & fees
Jun 29 - Jun 30
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHGAnderson
9.2 out of 10, Wonderful, (627 reviews)
"Room was clean and customer service was excellent, check in was smooth "
Gina
The price is CA $156
CA $173 total
includes taxes & fees
Jul 4 - Jul 5
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca ClemsonSeneca
9.2 out of 10, Wonderful, (855 reviews)
"Room was clean staff was great breakfast was good"
Jason
The price is CA $150
CA $165 total
includes taxes & fees
Jul 4 - Jul 5
Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,002 reviews)
"This was such a great hotel! The staff were so nice and friendly, the hotel and room were clean and comfy. I would definitely stay again and recommend to others. "
Melissa
The price is CA $197
CA $219 total
includes taxes & fees
Jul 5 - Jul 6
Fairfield Inn & Suites by Marriott Greenville Simpsonville
Fairfield Inn & Suites by Marriott Greenville SimpsonvilleSimpsonville
9.0 out of 10, Wonderful, (733 reviews)
"Great stay!"
Nayeli
The price is CA $125
CA $138 total
includes taxes & fees
Jul 5 - Jul 6
Comfort Inn & Suites Greer - Greenville
Comfort Inn & Suites Greer - GreenvilleGreer
8.6 out of 10, Excellent, (809 reviews)
"Great staff and a really good location for my needs."
David
The price is CA $147
CA $165 total
includes taxes & fees
Jun 28 - Jun 29
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
9.0 out of 10, Wonderful, (1,286 reviews)
"Great stay at a great price."
Janet
The price is CA $170
CA $187 total
includes taxes & fees
Jul 19 - Jul 20
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University AreaClemson
8.2 out of 10, Very good, (1,002 reviews)
"Great breakfast and friendly staff made our stay enjoyable."
Lon
The price is CA $152
CA $169 total
includes taxes & fees
Jul 4 - Jul 5
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Upstate South Carolina
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (80 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Upstate South Carolina attractions
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina
Top Upstate South Carolina Hotel Reviews
Drury Inn & Suites Greenville
8/10 Good
More cheap stays in Upstate South Carolina
Days Inn by Wyndham Greenville
60 Roper Mountain Rd Greenville SC
The price is CA $90 per night from Jun 28 to Jun 29
CA $90
CA $99 total
Jun 28 - Jun 29
includes taxes & fees
5.6/10 (1,005 reviews)
Hotels in Upstate South Carolina with star rating
4 Star Hotels
32 properties
Explore a world of travel with Expedia
- Hotels near Bob Jones University
- Hotels near Bon Secours Wellness Arena
- Hotels near Centre Stage
- Colonel Elias Earle Historic District Hotels
- Greenville County Hotels
- Hotels near Donaldson Center
- Hotels near Falls Park on the Reedy
- Five Forks Hotels
- Hotels near Fluor Field at the West End
- Hotels with smoking rooms in Gantt
- Golden Grove Hotels
- Green Avenue Hotels
- Hotels near Greenville Convention Center
- Hotels near Greenville Downtown
- Greenville Downtown Hotels
- Greenville Hotels
- Greenville - Spartanburg Hotels
- Hotels near Greenville Station
- Hotels near Greenville Zoo
- Hampton-Pinckney Historic District Hotels
- Hotels near Haywood Mall
- Hotels near Heritage Park
- Judson Hotels
- Cheap Hotels in Mauldin
- Luxury Hotels in Mauldin
- Pet-Friendly Hotels in Mauldin
- Spa Hotels in Mauldin
- Mauldin Hotels
- Payne-Logan Hotels
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Shriners Hospitals for Children Greenville
- Simpsonville Hotels
- Hotels near Swamp Rabbit Trail
- Hotels near The Peace Center
- West End Hotels
- Flights to Simpsonville
- Flights from Donaldson Center
- Flights from Greenville Downtown
- Flights from Mauldin
- Flights from Dunean
- Flights from Anderson (AND) to Greenville (GDC)
- Flights from Anderson (AND) to Greenville (GMU)
- Flights from Atlanta (ATL) to Greenville (GMU)
- Flights from Asheville (AVL) to Greenville (GDC)
- Flights from Birmingham (BHM) to Greenville (GMU)
- Flights from Burlington (BTV) to Greenville (GDC)
- Flights from Clemson (CEU) to Greenville (GDC)
- Flights from Danville (DAN) to Greenville (GDC)
- Flights from Washington (DCA) to Greenville (GDC)
- Flights from Denver (DEN) to Greenville (GDC)
- Flights from Des Moines (DSM) to Greenville (GDC)
- Flights from Detroit (DTW) to Greenville (GDC)
- Flights from Detroit (DTW) to Greenville (GMU)
- Flights from Newark Liberty Intl. Airport (EWR) to Greenville (GDC)
- Flights from Rome (FCO) to Greenville (GDC)
- Flights from Fort Lauderdale (FLL) to Greenville (GMU)
- Flights from Gatlinburg (GKT) to Greenville (GDC)
- Flights from Gatlinburg (GKT) to Greenville (GMU)
- Flights from Greenwood (GRD) to Greenville (GDC)
- Flights from Greenwood (GRD) to Greenville (GMU)
- Flights from Huntsville (HSV) to Greenville (GMU)
- Flights from Islip (ISP) to Greenville (GMU)
- Flights from Jacksonville (JAX) to Greenville (GMU)
- Flights from New York (JFK) to Greenville (GDC)
- Flights from New York (JFK) to Greenville (GMU)
- Flights from Las Vegas (LAS) to Greenville (GDC)
- Flights from Pickens (LQK) to Greenville (GDC)
- Flights from Orlando (MCO) to Greenville (GDC)
- Flights from Harrisburg (MDT) to Greenville (GMU)
- Flights from Manteo (MEO) to Greenville (GMU)
- Flights from Miami (MIA) to Greenville (GDC)
- Flights from Miami (MIA) to Greenville (GMU)
- Flights from New Orleans (MSY) to Greenville (GMU)
- Flights from Chicago (ORD) to Greenville (GDC)
- Flights from Chicago (ORD) to Greenville (GMU)
- Flights from Norfolk (ORF) to Greenville (GMU)
- Flights from West Palm Beach (PBI) to Greenville (GMU)
- Flights from Philadelphia (PHL) to Greenville (GMU)
- Flights from Portland (PWM) to Greenville (GMU)
- Flights from Raleigh (RDU) to Greenville (GMU)
- Flights from Rocky Mount (RWI) to Greenville (GMU)
- Flights from San Antonio (SAT) to Greenville (GDC)
- Flights from Savannah (SAV) to Greenville (GMU)
- Flights from Schenectady (SCH) to Greenville (GMU)
- Flights from Louisville (SDF) to Greenville (GMU)
- Flights from Sanford (SFM) to Greenville (GMU)
- Flights from Newburgh (SWF) to Greenville (GMU)
- Flights from Montreal (YUL) to Greenville (GMU)
- Flights from Vancouver (YVR) to Greenville (GMU)
- Flights from Toronto (YYZ) to Greenville (GDC)
- Flights from Toronto (YYZ) to Greenville (GMU)
